منابع مشابه
hdac inhibitors in neurodegenerative disorders
neurodegenerative disorders such as huntingtons disease, alzheimers disease, parkinsons disease, amyotrophic lateral sclerosis, spinal muscular atrophy, friedreichs ataxia, and others are multi-factorial illnesses in which many pathways (still poorly understood) act serially and in parallel to give a determined pathologic phenotype. thus, presently there are no effective cures for these disease...
متن کاملHDAC Inhibitors and Heat Shock Proteins (Hsps)
Epigenetic alterations, including DNA acetylation, hypermethylation and hypomethylation, and the associated transcriptional changes of the affected genes are central to the evolution and progression of various human cancers, including pancreatic cancer. Cancer-associated epigenetic alterations are attractive therapeutic targets because such epigenetic alterations, unlike genetic changes, are po...
متن کاملRational combinations using HDAC inhibitors.
In addition to well-characterized genetic abnormalities that lead to cancer onset and progression, it is now recognized that alterations to the epigenome may also play a significant role in oncogenesis. As a result, epigenetic-modulating agents such as histone deacetylase inhibitors (HDACi) have attracted enormous attention as anticancer drugs. In numerous in vitro and preclinical settings, the...
متن کاملHDAC inhibitors and cardiac safety.
To the Editors: Shah et al. (1) reported on the cardiotoxicity of the histone deacetylase inhibitor Romidepsin (depsipeptide, FK228) administered weekly 3 q28, in 15 patients with metastatic neuroendocrine tumors. The study was terminated early due to a high number of ‘‘serious cardiac adverse events’’ comprising of one sudden death, asymptomatic grade 2 ventricular tachycardia in two patients,...
متن کاملHDAC inhibitors: applications in oncology and beyond
Inhibitors of the histone deacetylases (HDACIs), a class of small molecules primarily involved in the modification of epigenetic regulation, have been exploited widely for their anti-cancer effects and/or chemo/ radio-sensitization properties. The mechanisms of action of several HDACIs have been unraveled that include modifications of histone acetylation status influencing gene expression and/o...
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ژورنال
عنوان ژورنال: Nature Reviews Clinical Oncology
سال: 2019
ISSN: 1759-4774,1759-4782
DOI: 10.1038/s41571-019-0224-2